The COVID-19 pandemic has revealed the stark need for African scientists and social scientists to generate policy-relevant research. Under the leadership of African School of Economics (ASE) and the Institut Pasteur of Côte d’Ivoire, African researchers are forming a Pan-African Scientific Research Council (PASRC). The Council was initiated by Leonard Wantchekon, Founder of ASE and Professor of Politics and International Affairs at Princeton University. In the short run, the Council will conduct original research that helps governments and societies respond to the novel coronavirus. In the medium- and long-term, the Council will address a range of challenges requiring research-driven responses, including food security, climate change, threats to biodiversity and political conflicts. The Council will support research, policy engagement, and capacity building. All active Africa-focused scientists and social scientists are invited to join these efforts.